The placental type plasminogen activator inhibitor, PAI-2.
نویسندگان
چکیده
منابع مشابه
Role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) for prognosis in endometrial cancer.
BACKGROUND Urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) contribute to the invasiveness of many carcinomas. Here, we studied a possible association between cytosolic uPA and PA-1 concentrations in tumor tissue with prognosis in patients with endometrial cancer. METHODS Cytosolic concentrations of uPA and PAI-1 were determined in 69 primary endot...
متن کاملInteraction between Plasminogen Activator Inhibitor Type 1 ( PAI - 1 ) Bound to Fibrin and Either Tissue - type Plasminogen Activator
Plasminogen activation is catalyzed both by tissue-type(t-PA) and by urokinase-type plasminogen activator (u-PA). This reaction is controlled by plasminogen activator inhibitor type 1 (PAI-1) that is either present in plasma or bound to fibrin, present in a thrombus. We studied the mechanism of in vitro inhibition of both t-PA and u-PA activity by PAI-1 bound to fibrin. It is shown that activat...
متن کاملType 1 Plasminogen Activator Inhibitor
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متن کاملDistribution of plasminogen activator inhibitor (PAI-1) in tissues.
Extracts of human tissue were analysed for plasminogen activator inhibitor (PAI-1) antigen and activity. PAI-1 was localised in tissues by an immunochemical method, using monoclonal antibodies. PAI-1 occurred throughout the body; its concentration and activity differed considerably from organ to organ. Extracts of liver and spleen had the greatest abundance of PAI-1, but the activity of the inh...
متن کاملEstrogen regulates endothelial migration via plasminogen activator inhibitor (PAI-1).
Endothelial plasminogen activator inhibitor (PAI-1) controls vascular remodeling, angiogenesis and fibrinolysis. PAI-1 blood levels in women are related to estrogen. The aim of this study was to characterize the signaling pathways through which estrogen regulates PAI-1 in endothelial cells. Furthermore, we aimed to investigate whether PAI-1 is implicated in the control of endothelial migration ...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1989
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.20.121